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Updated: Jul 30, 2026

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
10:33

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors

Published on: October 26, 2015

サイトクロームP450カムの活性部位およびその部位指向変異体の水素結合相互作用

T Deng1, I D Macdonald, M C Simianu

  • 1Department of Chemistry, Marquette University, Wehr Chemistry Building, P.O. Box1881 (535 North 14th Street, 53233), Milwaukee, Wisconsin 53201-1881, USA.

Journal of the American Chemical Society
|July 18, 2001
PubMed
まとめ

共振ラーマン光譜法により,シトクロームP450camのシアン酸添加物は,線形コンフォマーと曲線コンフォマーの両方を形成することを明らかにします. 曲った形は,H結合ドナーの影響を受け,基質結合に対する方向性を変化させ,ヘム構造に影響を与えます.

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