亜鉛指コアの反応性:タンパク質包装と静電スクリーニングの分析

A T Maynard1, D G Covell

  • 1Frederick Cancer Research and Development Center, Screening Technologies Branch, DCTD, NCI, NIH, SAIC, Frederick, Maryland 21702, USA. covell@faxpdc.ncifcrf.gov

まとめ

亜鉛指は反応性チオラートをシールドするために進化し,安定性はタンパク質環境によって異なります. 人間のエストロゲン受容体と同様に,不安定な亜鉛指は,レドックス調節され,転写と癌の進行に影響を与える可能性があります.

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