関連する実験動画

Updated: Jul 27, 2026

Protocol for the Solid-phase Synthesis of Oligomers of RNA Containing a 2'-O-thiophenylmethyl Modification and Characterization via Circular Dichroism
11:37

Protocol for the Solid-phase Synthesis of Oligomers of RNA Containing a 2'-O-thiophenylmethyl Modification and Characterization via Circular Dichroism

Published on: July 28, 2017

イソグアナシンとイソチチジンを含むRNA複合体の安定性と構造

X Chen1, R Kierzek, D H Turner

  • 1Department of Chemistry, University of Rochester, Rochester, New York 14627-0216, USA.

Journal of the American Chemical Society
|July 18, 2001
PubMed
まとめ

RNA複合体におけるイソグアナシン (iG) とイソシチジン (iC) の置換は,一般的に安定性を高め,安定化効果は配列に依存する. この発見は,核酸の熱力学と構造的性質を理解するために極めて重要です.

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Overview
The basic structure of RNA consists of a five-carbon sugar and one of four nitrogenous bases. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
Different Types of RNA Have the Same Basic Structure
There are three main types of ribonucleic acid (RNA): messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three RNA types consist of a...
RNA Stability01:53

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