関連する実験動画
Updated: Jun 19, 2026
14:18
A Strategy for Sensitive, Large Scale Quantitative Metabolomics
Published on: May 27, 2014
テトラデカ-2,6-O-メチル-ベータ-サイクロデクストリンの擬多形態:アルキル化ベータ-サイクロデクストリンの分子における2つの新しい水素の結晶構造-形状的変動性
J J Stezowski1, W Parker, S Hilgenkamp
1Contribution from the Department of Chemistry, Center for Materials Research and Analysis, University of Nebraska, Lincoln, Nebraska 68588-0304, USA.
Journal of the American Chemical Society
|July 18, 2001
まとめ
テトラデカ-2,6-O-メチル-ベータ-サイクロデクストリンは,異常なマイナス熱溶解性を示しています. 結晶構造は,このβ-サイクロデクストリン誘導体における構造的柔軟性と温度依存の水分化を明らかにします.
科学分野:
- 超分子化学 超分子化学
- クリスタルグラフィーです.
- 炭水化物化学 炭水化物の化学
背景:
- ベータ・サイクロデキストリン (β-CD) は,水害性空洞を持つ周期性オリゴサッカライドです.
- メチル化β-サイクロデクストリンは,様々な用途で広く使用されています.
- テトラデカ-2,6-O-メチル-β-サイクロデクストリン (per-2,6-OMe-β-CD) は,ユニークな溶解性を示しています.
研究 の 目的:
- パー-2,6-OMe-β-CD水合物の結晶構造を解明する.
- 結晶化温度が構造に与える影響を調査する.
- per-2,6-OMe-β-CDの形状の柔軟性を理解するために.
主な方法:
- 単結晶X線 difrakcion. 単結晶X線 difraktion. 単結晶X線 difraktion. 単結晶X線 difraktion. 単結晶X線 difraktion. 単結晶X線 difraktion. 単結晶X線 difraktion. 単結晶X線 difraktion. 単結晶X線 difraktion. 単結晶X線 difraktion. 単結晶X線 difraktion. 単結晶X線 difraktion. 単結晶X線 difraktion.
- 制御された温度 (4°Cと50°C) で結晶化.
- ハイドレート形態の構造分析.
主要な成果:
- パー-2,6-OMe-β-CDヒドレットの2つの新しい結晶構造が決定されました:パー-2,6-OMe-β-CD·1.08H(2) Oとパー-2,6-OMe-β-CD·14.7H(2) O.
- per-2,6-OMe-β-CD·1.08H(2) Oの結晶構造は,形状の柔軟性を明らかにした.
- 乱れたグルコース残留と温度に依存する水分子の占有量が観察されました.
結論:
- 結晶構造は,per-2,6-OMe-β-CD水合物の分子配置についての洞察を提供します.
- 形状の柔軟性は,このメチル化されたβ-サイクロデキストリンの重要な特徴です.
- 温度が水分化レベルと構造的な詳細に大きな影響を与えます.
関連する概念動画
02:34Structural Isomerism
Isomerism in Complexes
Isomers are different chemical species that have the same chemical formula. Structural isomerism of coordination compounds can be divided into two subcategories, the linkage isomers and coordination-sphere isomers.
Linkage isomers occur when the coordination compound contains a ligand that can bind to the transition metal center through two different atoms. For example, the CN− ligand can bind through the carbon atom or through the nitrogen atom. Similarly, SCN− can be...
Isomers are different chemical species that have the same chemical formula. Structural isomerism of coordination compounds can be divided into two subcategories, the linkage isomers and coordination-sphere isomers.
Linkage isomers occur when the coordination compound contains a ligand that can bind to the transition metal center through two different atoms. For example, the CN− ligand can bind through the carbon atom or through the nitrogen atom. Similarly, SCN− can be...
02:52Stereoisomerism
Isomerism in Complexes
Isomers are different chemical species that have the same chemical formula.
Transition metal complexes often exist as geometric isomers, in which the same atoms are connected through the same types of bonds but with differences in their orientation in space. Coordination complexes with two different ligands in the cis and trans positions from a ligand of interest form isomers. For example, the octahedral [Co(NH3)4Cl2]+ ion has two isomers (Figure 1) In the cis...
Isomers are different chemical species that have the same chemical formula.
Transition metal complexes often exist as geometric isomers, in which the same atoms are connected through the same types of bonds but with differences in their orientation in space. Coordination complexes with two different ligands in the cis and trans positions from a ligand of interest form isomers. For example, the octahedral [Co(NH3)4Cl2]+ ion has two isomers (Figure 1) In the cis...
02:43Isomerism
Isomers are molecules with the same molecular formula but different structural arrangements. Isomers can be further classified into constitutional isomers and stereoisomers. Constitutional isomers differ in the connectivity of their constituent atoms. For example, 2-butanol and diethyl ether are constitutional isomers, as they have the same chemical formula, C4H10O, but differ in the connectivity of the carbon and oxygen atoms. Constitutional isomers have different physical and chemical...
02:01Isomerism in Alkenes
Alkenes like 1-butene and 2-butene exhibit constitutional isomerism, as they differ in the position of the double bond. Further, 2-butene exhibits stereoisomerism and exists as two distinct compounds differing in spatial arrangement.
An isomer is called cis-2-butene when the methyl groups are on the same side of the double bond, and the other stereoisomer, in which methyl groups are on the opposite side of the double bond, is called trans-2-butene. The cis and trans stereoisomers are not...
An isomer is called cis-2-butene when the methyl groups are on the same side of the double bond, and the other stereoisomer, in which methyl groups are on the opposite side of the double bond, is called trans-2-butene. The cis and trans stereoisomers are not...
01:28Structures of Carboxylic Acid Derivatives
Structure of Carboxylic Acid Derivatives
Carboxylic acid derivatives contain an acyl group attached to a heteroatom such as chlorine, oxygen, or nitrogen. The carbonyl carbon and oxygen are both sp2-hybridized with an unhybridized p orbital.
The three sp2 orbitals of the carbonyl carbon form three σ bonds, one each with the carbonyl oxygen, the α carbon, and the heteroatom, whereas the other two sp2 orbitals of the carbonyl oxygen are occupied by the lone pairs. Further, the unhybridized p...
Carboxylic acid derivatives contain an acyl group attached to a heteroatom such as chlorine, oxygen, or nitrogen. The carbonyl carbon and oxygen are both sp2-hybridized with an unhybridized p orbital.
The three sp2 orbitals of the carbonyl carbon form three σ bonds, one each with the carbonyl oxygen, the α carbon, and the heteroatom, whereas the other two sp2 orbitals of the carbonyl oxygen are occupied by the lone pairs. Further, the unhybridized p...
01:29Imperfections in Crystal Structure: Non-Stoichiometric Defects
Non-stoichiometric defects refer to a type of defect in the crystal structure of a compound where the ratio of its constituent elements deviates from the ideal stoichiometric ratio. There are two main types of non-stoichiometric defects: metal excess defects and metal deficiency defects.Metal excess defects occur when there is a slight surplus of metal ions than what is required by the stoichiometric ratio of the compound. For example, heating a sodium chloride crystal in sodium vapor results...