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関連する概念動画

The Nucleus01:32

The Nucleus

The nucleus is a membrane-bound organelle that acts as a control center in a eukaryotic cell. It contains chromosomal DNA, which controls gene expression and precisely regulates the production of proteins within the cell. In contrast, the DNA inside the mitochondria and chloroplast only carries out functions that are specific to those organelles.
Arrangement of DNA within Nucleus
The regulation of gene expression inside the nucleus is dependent on many factors, including the DNA structure. The...
The Nucleus01:25

The Nucleus

The nucleus is a membrane-bound organelle that acts as a control center in a eukaryotic cell. It contains chromosomal DNA, which controls gene expression and precisely regulates the production of proteins within the cell. In contrast, the DNA inside the mitochondria and chloroplast only carries out functions that are specific to those organelles.
Arrangement of DNA within Nucleus
The regulation of gene expression inside the nucleus is dependent on many factors, including the DNA structure. The...
Atomic Nuclei: Nuclear Spin01:08

Atomic Nuclei: Nuclear Spin

All atomic particles possess an intrinsic angular momentum, or 'spin'. Electrons, protons, and neutrons each have a spin value of ½, although protons and neutrons in nuclei may have higher half-integer spins owing to energetic factors.
Atomic nuclei have a net nuclear spin, , which can have an integer or half-integer value. In atomic nuclei, the spins of protons are paired against each other but not with neutrons, and vice versa. Consequently, an even number of protons does not contribute to...
Atomic Nuclei: Nuclear Spin State Overview01:03

Atomic Nuclei: Nuclear Spin State Overview

NMR-active nuclei have energy levels called 'spin states' that are associated with the orientations of their nuclear magnetic moments. In the absence of a magnetic field, the nuclear magnetic moments are randomly oriented, and the spin states are degenerate. When an external magnetic field is applied, the spin states have only 2 + 1 orientations available to them. A proton with = ½ has two available orientations. Similarly, for a quadrupolar nucleus with a nuclear spin value of one, the...
Toroids01:27

Toroids

A toroid is a closely wound donut-shaped coil constructed using a single conducting wire. In general, it is assumed that a toriod consists of multiple circular loops perpendicular to its axis.
When connected to a supply, the magnetic field generated in the toroid has field lines circular and concentric to its axis. Conventionally, the direction of this magnetic field is expressed using the right-hand rule. If the fingers of the right hand curl in the current direction, the thumb points in the...
The Nucleus01:25

The Nucleus

The nucleus is a membrane-bound organelle that acts as a control center in a eukaryotic cell. It contains chromosomal DNA, which controls gene expression and precisely regulates the production of proteins within the cell. In contrast, the DNA inside the mitochondria and chloroplast only carries out functions that are specific to those organelles.
Arrangement of DNA within Nucleus
The regulation of gene expression inside the nucleus is dependent on many factors, including the DNA structure. The...

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A Direct Force Probe for Measuring Mechanical Integration Between the Nucleus and the Cytoskeleton
05:47

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Published on: July 29, 2018

フロアースコアを備えたコイル状のコイルです.

B Bilgiçer1, A Fichera, K Kumar

  • 1Department of Chemistry, Tufts University, Medford, Massachusetts 02155, USA.

Journal of the American Chemical Society
|July 18, 2001
PubMed
まとめ
この要約は機械生成です。

この研究では,安定性を高めるためにフッ素ペプチドシステムを設計しました. 新型フッ素ペプチドは,炭化水素同位体と比較して,安定性が向上し,融点も高いことを示した.

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科学分野:

  • バイオケミストリー バイオケミストリー
  • ペプチド化学 ペプチド化学
  • 構造生物学 構造生物学とは

背景:

  • コイルされたコイル構造は,タンパク質とタンパク質の相互作用において極めて重要です.
  • 安定したペプチドシステムの設計は,バイオ分子アプリケーションにとって重要です.
  • 酸化アミノ酸はペプチドの改変にユニークな特性を提供します.

研究 の 目的:

  • GCN4コイルコイルをベースにした高フッ素ペプチドシステムを設計・合成する.
  • フッ素ペプチドの構造と安定性の特性を調査する.
  • 自己組み立てシステムにおけるフッ素ペプチドの可能性を調査する.

主な方法:

  • 非自然なアミノ酸 (5,5,5-トリフルオロウシンと4,4,4-トリフルオロヴァリン) を含むペプチドの設計と合成.
  • 二次構造を評価するために,円形の二重化スペクトロスコーピーを用いる.
  • オリゴメア状態を決定するために,分析用超離心分離.
  • グアニジニウム塩化水素のデナチュレーション実験で,自由エネルギーの展開を測定する.

主要な成果:

  • フッ素ペプチドは溶液中のアルファヘリル性が高い.
  • 安定した二次元種を形成する.
  • フッ素ペプチドは,炭化水素対照と比較して15°C高い融解温度と安定性の向上を示しています.
  • 展開の明らかな自由エネルギーは,フッ素ペプチドの場合は約1.0 kcal/mol以上である.

結論:

  • トリフローロメチル基の組み込みはペプチドの安定性を高めます.
  • 水性トリフルオロメチル基は水性溶媒から効果的に隔離されます.
  • この研究は,直角の溶解性特性を用いて自己組み立てシステムを設計するための新しいアプローチを提示しています.