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Peptide-based Identification of Functional Motifs and their Binding Partners
Published on: June 30, 2013
ヒト免疫不全ウイルス-1プロテアース阻害剤の使用は,アテロゲン性リポプロテインの変化と内皮機能不全と関連しています
J H Stein1, M A Klein, J L Bellehumeur
1Department of Medicine, University of Wisconsin Medical School, Madison, Wisconsin, USA.
Circulation
|July 18, 2001
まとめ
ヒト免疫不全ウイルスプロテアース阻害剤 (HIV PIs) は,コレステロールの有害な変化を引き起こし,血管機能を損ない,動脈硬化のリスクを増大させます. これらの薬剤を服用している患者における脂質不全症のモニタリングと治療は極めて重要です.
科学分野:
- 心血管医学は,心臓血管医学である.
- 感染症 感染症は感染症です.
- 薬理学 薬理学とは
背景:
- ヒト免疫不全ウイルスプロテアゼ阻害剤 (HIV PIs) は,高脂血症や肥満などの代謝問題に関連しています.
- 動脈硬化性血管疾患のリスクに対するHIVPIの影響は不明である.
- この研究では,PIを使用したHIV感染者におけるリポプロテイン異常と内皮機能を調査しています.
研究 の 目的:
- PIsのHIV患者におけるリポプロテイン異常を特徴付けるために.
- これらの変化が内皮機能不全に及ぼす病理生理学的重要性を評価する.
主な方法:
- 抗レトロウイルス治療を受けている37人のHIV-1感染成人に関する横断的研究.
- PIに関する22件 (グループ1) と,PIに関する15件 (グループ2) に分けられる.
- 測定された脂質,リポタンパク質 (酵素,NMR),および腕動脈の流れ媒介血管拡張 (FMD) を超音波で測定した.
主要な成果:
- グループ1は総コレステロールとトリグリセリドが高く,IDLとVLDLレベルが上昇した.
- グループ1は,有意な内皮機能不全を示唆する FMD (2.6+/-4.6%) の障害を示した.
- グループ2は正常な口腔炎 (8.1+/-6.7%) を示した.
- リポプロテインレベル (キロミクロン,VLDL,IDL,HDL) は,グループ1における口腔炎を予測した.
結論:
- HIV PIsは,アテロゲン性リポプロテインの変化と内皮機能障害に関連しています.
- これらの代謝および血管の変化は,動脈硬化症への予備性を高めます.
- 定期的なモニタリングとディスリピデミアの管理は,HIV PIsの患者に推奨されます.
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