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Updated: May 7, 2026

Assessing Somatic Hypermutation in Ramos B Cells after Overexpression or Knockdown of Specific Genes
08:12

Assessing Somatic Hypermutation in Ramos B Cells after Overexpression or Knockdown of Specific Genes

Published on: November 1, 2011

B細胞の拡散型大細胞リンパ腫における複数のプロトオンコゲンの高変異

L Pasqualucci1, P Neumeister, T Goossens

  • 1Institute for Cancer Genetics and the Department of Pathology, Columbia University, New York, New York 10032, USA.

Nature
|July 19, 2001
PubMed
まとめ

異常な超変異活動は,拡散型大細胞リンパ腫 (DLCL) の重要な遺伝子を標的とし,ゲノム全体の不安定性を引き起こします. ソマティック・ハイパーミューテーションのこの機能不全は,これらの生殖中心から派生した腫瘍におけるリンパマゲネシスに大きく寄与している可能性があります.

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