健康な若年成人における冠動脈循環に対する被動喫煙の急性影響
R Otsuka1, H Watanabe, K Hirata
1Department of Internal Medicine and Cardiology, Osaka City University Medical School, 1-4-3 Asahimachi Abeno-ku, Osaka City, Japan 545-8585.
JAMA
|July 31, 2001
まとめ
パッシブ喫煙は,健康な非喫煙者の冠動脈循環を著しく損なっており,冠動脈流動速度準備 (CFVR) を減少させます. この研究は,二手喫煙が心臓の内皮機能不全を引き起こす証拠を提供します.
科学分野:
- 心血管生理学 心血管の生理学
- 環境衛生 環境衛生 環境衛生
- 非侵襲的な心臓病学
背景:
- パッシブ喫煙は,心不全性疾患の既知の危険因子です.
- 血管内皮機能不全は,被動喫煙の暴露と関連しています.
- 非喫煙者の冠動脈循環に対する被動喫煙の急性影響は不明である.
研究 の 目的:
- 冠動脈循環に対する被動喫煙の急性影響を評価する.
- 冠動脈流動速度準備量 (CFVR) を重要な指標として利用する.
- 評価のために,非侵襲的トランストラシックドップラーエコーカルディオグラフィーを採用します.
主な方法:
- 30人の日本人男性 (15人の健康な非喫煙者,15人の喫煙者) を対象とした横断的な研究.
- アデノシントライホスファート誘発性高血症を用いてCFVRを測定した.30分間の環境喫煙露出前および後.
- 参加者は高血圧,糖尿病,高脂血症のスクリーニングを受けました.
主要な成果:
- パッシブ喫煙は,アデノシントリフォスファートに対する心拍数や血圧の反応に影響しませんでした.
- 基礎動脈冠動脈の流動速度への影響は,いずれのグループでも観察されなかった.
- パッシブ喫煙は,健康な非喫煙者においてCFVRを著しく低下させた (4.4~3.4,P<.001).
結論:
- パッシブ喫煙は,健康な非喫煙者の冠動脈の流れ速度を大幅に減少させる.
- 研究結果は,被動的煙の曝露が冠動脈循環における内皮機能不全を引き起こすことを示唆している.
- 心血管の健康に対する二手喫煙の直接的な有害な影響を強調する.
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