急性心筋梗塞におけるボラスのフィブリノリチック療法
J Llevadot1, R P Giugliano, E M Antman
1TIMI Study Group, 333 Longwood Ave, Suite 402, Boston, MA 02115, USA.
JAMA
|July 31, 2001
まとめ
テネクテプラス,レテプラスなどの新しいボラスフィブリノリチク薬は,急性心筋梗塞の治療に便利な投与を提供します. それらは組織型プラズミノゲン活性化剤 (tPA) と比較可能な有効性と安全性を示し,再注射療法における重要な役割を果たしていることを示唆しています.
科学分野:
- 心臓病学 心臓病学
- 薬理学 薬理学とは
- トロンボシスの管理
背景:
- ヒト組織型プラズミノゲン活性化剤 (tPA) から派生した新しいボラスのフィブリノリチックは,急性心筋梗塞における閉塞性血栓症の治療のために出現しています.
- これらの薬剤は,血栓をより効果的かつ便利に溶かすことを目的としています.
研究 の 目的:
- 新型ボラスのフィブリノリチス薬:レテプラス,ラノテプラス,テネクテプラスをレビューする.
- 薬剤の薬理 Untuak manilai farmakokinetika, farmakodinamika,および臨床結果.
主な方法:
- MEDLINE,EMBASE,および現在のコンテンツのデータベース (1983-2001) で検索しました.
- レテプラス,ラノテプラス,テネクテプラスの薬物動態学,薬物動態学,および臨床結果に関する研究が含まれています.
- 特定された138件の論文のうち38件を分析し,ピアレビューされた出版物または会議プレゼンテーションを通じてデータの質を評価しました.
主要な成果:
- テネクテプラスとレテプラスは,加速輸注による再結合tPAに匹敵する有効性と安全性を実証しており,ボラス投与により便利性が向上しています.
- ラノテプラスはヘパリンと併用され,tPAと同様の死亡率を示しているが,頭蓋内出血の発生率は著しく高い.
結論:
- ボルスのフィブリノリート投与は,かなり便利です.
- 加速輸液再結合tPAに匹敵する結果を考慮すると,ボラスのフィブリノリチックは,急性心筋梗塞に対する現代の再注血戦略の不可欠な部分である可能性が高い.
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