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Updated: Jun 21, 2026

Probing High-density Functional Protein Microarrays to Detect Protein-protein Interactions
08:07

Probing High-density Functional Protein Microarrays to Detect Protein-protein Interactions

Published on: August 2, 2015

プロテオームチップを用いたタンパク質活動の総合分析

H Zhu1, M Bilgin, R Bangham

  • 1Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520, USA.

Science (New York, N.Y.)
|July 28, 2001
PubMed
まとめ

研究者は,タンパク質の相互作用を研究するために,酵母タンパク質マイクロアレイを作成しました. このツールは,新しいカルモジュリンとリン脂結合タンパク質を特定し,薬物スクリーニングとタンパク質の改変を理解するための道を切り開きました.

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An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
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