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Updated: Jun 24, 2026

A GPC3-targeting Bispecific Antibody, GPC3-S-Fab, with Potent Cytotoxicity
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CD36欠乏症とインスリン抵抗性

J R Petrie, M Collison, J M Connell

    Lancet (London, England)
    |August 2, 2001
    PubMed
    まとめ

    No abstract available in PubMed .

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    A GPC3-targeting Bispecific Antibody, GPC3-S-Fab, with Potent Cytotoxicity
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    Receptor Downregulation in MVBs

    Multivesicular bodies (MVBs) are mature endosomes that sort ubiquitinated proteins and then fuse with lysosomes to degrade the sorted proteins. Epidermal growth factor (EGF) and its receptor (EGFR) form a complex that can be internalized through endocytosis, sorted into an MVB, and later degraded.
    The EGFR can initiate signaling pathways that  lead to cell proliferation, migration, and differentiation. Overexpression of EGFR  stimulates cells to proliferate. Excessive  EGFR activation may...

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