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Updated: Jun 21, 2026

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エリソポエチン媒介の神経保護には,Jak2とNF-kappaBのシグナリングカスケード間のクロストークが含まれています

M Digicaylioglu1, S A Lipton

  • 1Center for Neuroscience and Aging Research, The Burnham Institute, La Jolla, CA 92037, USA.

Nature
|August 9, 2001
PubMed
まとめ

エリトロポエチン (EPO) プリコンディショニングは,ニューロンのEPO受容体を活性化することによって,損傷から脳細胞を保護します. これは,ジャヌスキナーゼ-2 (Jak2) と核因子-カッパB (NF-kappaB) を含む新しいシグナル伝達経路を誘発し,ニューロンの死を予防します.

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