幼児期における大豆ベースの配方食品への暴露,若年成人期における内分泌学的および生殖学的結果
B L Strom1, R Schinnar, E E Ziegler
1University of Pennsylvania, Center for Clinical Epidemiology and Biostatistics, 824 Blockley Hall, 423 Guardian Dr, Philadelphia, PA 19104-6021, USA. bstrom@cceb.med.upenn.edu
JAMA
|August 22, 2001
まとめ
乳児の豆乳配粉への曝露は,牛乳配粉と比較して,長期的な健康上の有意な違いを示さなかった. 一部の女性は,更期の出血や不快感が長くなると報告し,大豆イソフラボン効果のさらなる調査を正当化しました.
科学分野:
- エンドクリノロジー エンドクリノロジー
- 小児の栄養について
- 生殖器保健は,生殖器の健康についてです.
背景:
- フィトエストロゲンは,大豆イソフラボンと同様に,ホルモン依存状態に影響を与えます.
- 乳児は,重要な発達期に,高用量の植物エストロゲンを摂取します.
- 乳児用大豆配粉の長期的健康への影響に関するデータは限られている.
研究 の 目的:
- 乳児用大豆粉の摂取と,若い成人期における健康上の結果との関連性を調査する.
- 具体的には,乳児の時に大豆配粉に曝された成人の生殖健康に対する長期的な影響を調査する.
主な方法:
- 20歳から34歳までの成人を対象とした遡及的なコホート研究.
- 参加者は,乳児の栄養:大豆配粉 (n=248) または牛乳配粉 (n=563) に基づいて分類されました.
- 収集されたデータには,自己報告された思春期の成熟,生殖歴,および一般的な健康状態が含まれています.
主要な成果:
- 30以上の健康または生殖に関する結果において,大豆と牛乳配方グループの間で統計的に有意な差は見つかりませんでした.
- 豆乳を摂取した女性は,月経出血の期間がわずかに長かった (0.37日) と報告した.
- 豆乳を摂取した女性は,月経不快感が増加したと報告した (RR 1.77).
結論:
- 乳児の豆乳配粉への曝露は,牛乳配粉と比較して,一般的または生殖的健康への悪影響を及ぼさないようです.
- 月経の特徴に関するいくつかの発見は,さらなる研究が必要ですが,この研究は,大豆乳児用栄養素の安全性について安心感を与えています.
- 乳児用ミルクから摂取される大豆イソフラボンの長期的な効果については,継続的な調査が必要である.
関連する概念動画
01:41Spermatogenesis
Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male reproductive...
01:38Fertilization
During fertilization, an egg and sperm cell fuse to create a new diploid structure. In humans, the process occurs once the egg has been released from the ovary, and travels into the fallopian tubes. The process requires several key steps: 1) sperm present in the genital tract must locate the egg; 2) once there, sperm need to release enzymes to help them burrow through the protective zona pellucida of the egg; and 3) the membranes of a single sperm cell and egg must fuse, with the sperm...
01:07Teratogenicity
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
01:22Development of Immunocompetence
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
01:30Development of Human Microbiota
The human microbiota begins developing at birth and undergoes continual change as we age. Infancy marks a critical period of microbial sensitivity, offering a “window of opportunity” during which beneficial microbes help mature the immune system. By age three, children typically develop a more stable and diverse microbial community. Newborns acquire microbes from their immediate environment; vaginal delivery favors maternal vaginal microbes, while cesarean births favor microbes from the skin...
01:28Development of the Oral Microbiota
The establishment of the oral microbiome begins before birth, challenging the long-held belief that the fetal oral cavity is sterile. The presence of oral microbes such as Streptococcus and Fusobacterium in amniotic fluid suggests that microbial exposure may occur in utero, potentially through translocation from the maternal oral or gastrointestinal tract. This early colonization primes the neonatal immune system and sets the stage for subsequent microbial succession. Maternal health,...