周周血液または骨髄移植後の妊娠の結果:遡及的調査
N Salooja1, R M Szydlo, G Socie
1Department of Haematology, Imperial College of Science and Medicine, Hammersmith Hospital, London, UK.
Lancet (London, England)
|August 11, 2001
まとめ
幹細胞移植 (SCT) の後,生育能力は維持または回復することができます. 妊娠率は低いが,ほとんどの妊娠は生産を伴うが,アロインプラント受容者には高リスクの監視が必要である.
科学分野:
- 血液学 ヘマトロジ
- 生殖医学は,生殖器医学である.
- 腫瘍学 腫瘍学
背景:
- 幹細胞移植 (SCT) は,一部の患者で不妊症につながる可能性があります.
- SCTを受けた人によって,生殖能力の結果は異なります.
研究 の 目的:
- オトログ的またはオロジェニックのSCTを受けた患者の受胎と妊娠の結果を評価するために.
- SCT後の生育回復と妊娠成功率を評価する.
主な方法:
- 229の欧州血液・骨髄移植センターにアンケートが配布されました.
- 収集されたデータには,元の病気,移植の詳細,男性と女性の患者の受胎結果が含まれていました.
主要な成果:
- 232人 (0.6%) の患者がSCT後に妊娠し,生育率は1000生存者あたり1.7であった.
- 113人の患者とパートナーの間で312人の受精が報告され,その結果271人の生産が報告されました.
- アロ移植を受けた女性は,帝王切開,早産,低出生体重の子孫の割合が一般人よりも高かった.
結論:
- SCT後の妊娠は,一般的に成功しています.
- アロインプラント受容者,特に全身放射線を受けた受容者は,注意深い管理を必要とする高リスク妊娠に直面しています.
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