周辺の自律モジュールと,正常な膀機能と過活性の膀機能における筋筋のモデル
M J Drake1, I W Mills, J I Gillespie
1Tyne Micturition Research Group, School of Surgical Sciences, Medical School, University of Newcastle upon Tyne NE2 4HH, UK. marcus.drake@doctors.org.uk
Lancet (London, England)
|August 15, 2001
まとめ
周周神経系の活動は,前述の考えよりも膀のコントロールにおいて大きな役割を果たす可能性がある. この研究は,膀の過剰活動が,モジュラーなデトラサー筋構造内の周辺の自律活動における不均衡から生じることを示唆している.
科学分野:
- 泌尿器科 泌尿器科とは
- 神経科学は神経科学である.
- 生理学 生理学とは
背景:
- 膀の正常な機能は,主に中枢神経系 (CNS) の制御に起因する.
- 膀のコントロールに潜在的,しかし過小評価されている,周辺的貢献が存在する.
研究 の 目的:
- 外周神経系メカニズムを含む膀制御の新しいモデルを提案する.
- デトルーサーの過剰活動における周辺の自律的な活動の役割を調査する.
主な方法:
- モジュール型のデトラサー筋の配置の概念化.
- これらのモジュールを制御する外周筋を仮説化しています.
- 周辺の活動に基づくデトルーザー過活性の新しいメカニズムを提案する.
主要な成果:
- デトルーサーの筋肉は,機能的なモジュールに編成されることがあります.
- ガングリアとインタースティシャル細胞を含む外周筋筋は,これらのモジュールを調節する可能性があります.
- デトルーサーの過剰活性は,これらの周辺モジュール内の興奮抑制バランスの変化から生じる可能性があります.
結論:
- 周周神経系は膀の機能に大きな影響を与えます.
- デトルーサーの過剰活性は,周辺の自律的な活動の制御不全と関連している可能性があります.
- 周辺構造をターゲットにすることで,膀過活性の新たな治療戦略の可能性が生まれます.
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