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Updated: May 7, 2026

Technique of Minimally Invasive Transverse Aortic Constriction in Mice for Induction of Left Ventricular Hypertrophy
08:34

Technique of Minimally Invasive Transverse Aortic Constriction in Mice for Induction of Left Ventricular Hypertrophy

Published on: September 25, 2017

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腫瘍ネクロシス因子の過剰発現が心臓に制限されたトランスジェニックマウスにおける左心室リモデリング

N Sivasubramanian1, M L Coker, K M Kurrelmeyer

  • 1Winters Center for Heart Failure Research, Cardiology Section, Department of Medicine, Veterans Affairs Medical Center, Houston, TX 77030, USA.

Circulation
|August 15, 2001
PubMed
まとめ

腫瘍死滅因子 (TNF) は,マトリックスメタルプロテインアゼ (MMP) とメタルプロテインアゼの組織阻害剤 (TIMP) のバランスを変化させることで,心臓の改造を引き起こします. この研究では,MMP/TIMPの活性におけるTNF誘発による変化が,時間の経過とともに心筋コラーゲン含有量にどのように影響するかを明らかにしています.

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