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協調補助物を運ぶビニルエーテルの高度に地域選択的,連続的,および複数のパラジウム触媒のアリレーション:ヘックトリアリレーションプロセスの例
P Nilsson1, M Larhed, A Hallberg
1Department of Organic Pharmaceutical Chemistry, Uppsala Biomedical Center, Uppsala University, P.O. Box 574, SE-751 23 Uppsala, Sweden.
Journal of the American Chemical Society
|August 23, 2001
まとめ
研究者らは,パラジアム-調整型ジメチラミノ基を用いた新しい補助加速ヘックマルチアリレーションを開発した. これにより,最初のヘックトリアリレーションとビニルエーサーの選択的ダイアリレーションを含む,効率的なトライおよびダイアリレーション反応が可能になります.
科学分野:
- 有機化学 オーガニック・ケミストリー
- カタリシス カタリシス カタリシス
- 合成方法論 合成方法論
背景:
- ヘック反応は,C−C結合形成に不可欠である.
- 効率的で選択的なマルチアリレーション方法の開発は,依然として課題です.
- 補助誘導触媒は,反応性と選択性を制御するための経路を提供します.
研究 の 目的:
- 新しい補助加速ヘックマルチアリレーション反応を開発する.
- ケレーション制御のためにパラジアム調整型ジメチラミノ基を導入する.
- ヴィニルエーサーのトリ-およびダイアリレーションの効率的な方法を確立する.
主な方法:
- 酸化添加複合体の分子内プレゼンテーション.
- パラジアム調整型ダイメチラミノ基を用いて,ケレーション加速と制御を行う.
- 触媒誘導グループ除去のためのマイクロ波補助水解.
主要な成果:
- ヘックトライアリレーションプロセスの最初の例を報告した.
- アルキルビニルエーテルの高度選択的パラジウム触媒ダイアリレーションを達成しました.
- アミノ置換ビニルエーテルのための高速2相マイクロ波補助水解プロトコルを開発しました.
結論:
- ダイメチラミノ基は,ヘック多アリレーション反応を効果的に誘導し,加速する.
- 開発された方法は,ダイアリレートされたエタノールと代用されたデソキシベンゾインへの効率的なアクセスを提供します.
- 触媒誘導グループ除去は迅速かつ効率的で,製品の分離を簡素化します.
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