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Updated: Jul 13, 2026

In utero Electroporation followed by Primary Neuronal Culture for Studying Gene Function in Subset of Cortical Neurons
08:24

In utero Electroporation followed by Primary Neuronal Culture for Studying Gene Function in Subset of Cortical Neurons

Published on: October 9, 2010

変異性タウとAPPを発現するトランスジェニックマウスにおける強化神経線維細胞変性

J Lewis1, D W Dickson, W L Lin

  • 1Birdsall Building, Mayo Clinic Jacksonville, 4500 San Pablo Road, Jacksonville, FL 32224, USA.

Science (New York, N.Y.)
|August 25, 2001
PubMed
まとめ

研究者はタウとベータアミロイド前駆タンパク質 (APP) をマウスに交差させた. ダブルミュータントは神経線維細胞の絡み方が強化され,APPまたはAbetaが絡み形成に影響を与えることを示唆し,アルツハイマー病の病理学仮説を支持した.

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