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Updated: May 11, 2026

Assessing Somatic Hypermutation in Ramos B Cells after Overexpression or Knockdown of Specific Genes
08:12

Assessing Somatic Hypermutation in Ramos B Cells after Overexpression or Knockdown of Specific Genes

Published on: November 1, 2011

XRCC2/3のアブレーションにより,免疫グロブリンVの遺伝子変換は,体的ハイパーミューテーションに変化する

J E Sale1, D M Calandrini, M Takata

  • 1Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK. jes@mrc-lmb.cam.ac.uk

Nature
|August 31, 2001
PubMed
まとめ

鶏のB細胞におけるRAD51パラログを消去すると,免疫グロブリンVの遺伝子多様化は遺伝子変換から体性ハイパーミューテーションにシフトする. これは,ハイパーミューテーション経路とその修復メカニズムを研究するためのモデルを提供します.

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Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation

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Analysis of Somatic Hypermutation in the JH4 intron of Germinal Center B cells from Mouse Peyer's Patches09:35

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Published on: April 20, 2021

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X-inactivation01:58

X-inactivation

The human X chromosome contains over ten times the number of genes as in the Y chromosome. Since males have only one X chromosome, and females have two, one might expect females to produce twice as many of the proteins, with undesirable results.
Gene Conversion02:08

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