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Updated: Jul 27, 2026

Genome-wide Mapping of Drug-DNA Interactions in Cells with COSMIC (Crosslinking of Small Molecules to Isolate Chromatin)
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Genome-wide Mapping of Drug-DNA Interactions in Cells with COSMIC (Crosslinking of Small Molecules to Isolate Chromatin)

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DNA結合ポリアミド-カンプトテシン結合体によるトポイソメラーゼIのシーケンス固有のトラッピング

C C Wang1, P B Dervan

  • 1Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA.

Journal of the American Chemical Society
|September 6, 2001
PubMed
まとめ

DNAを標的とする合成ポリアミドは,カンプトセチンと結合された. これらの結合体はトポイソメラーゼIを捕まえて,特定の部位でDNAの分裂を誘導し,結合体3は高効率性を示しています.

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