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Assessment of Mitochondrial Functions and Cell Viability in Renal Cells Overexpressing Protein Kinase C Isozymes
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シトクロームP450カムの酸素活性化におけるThr 252の役割

D L Harris1, G H Loew

  • 1Molecular Research Institute, Palo Alto, California 94304, USA.

Journal of the American Chemical Society
|December 28, 1994
PubMed
まとめ

分子ダイナミクスシミュレーションでは,サイトクロームP450camのThreonine 252 (T252) がダイナミックな役割を果たしていることが明らかになりました. この残留物は,グリシン248 (G248) と酸素の両方と相互作用し,酵素-二酸化酸素複合体を安定させます.

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