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Updated: Jun 18, 2026

Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells
10:06

Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells

Published on: April 26, 2017

スプライシングに依存するエクソン-エクソン結合複合体におけるナンセンス媒介分解因子hUpf3の役割

V N Kim1, N Kataoka, G Dreyfuss

  • 1Howard Hughes Medical Institute and Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

Science (New York, N.Y.)
|September 8, 2001
PubMed
まとめ

無意味な媒介による衰退 (NMD) は,欠陥のあるmRNAを分解する. タンパク質hUpf3は,核から出る前に,エクソンの交差点の近くにあるスプライスされたmRNAに結合することによって,mRNAスプライシングをNMDとリンクします.

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