循環中の細胞粘着分子と冠動脈疾患の患者の死亡
S Blankenberg1, H J Rupprecht, C Bickel
1Department of Medicine II, Johannes Gutenberg-University Mainz, Germany. stefan.blankenberg@uni-mainz.de
Circulation
|September 19, 2001
まとめ
血管細胞粘着分子-1 (sVCAM-1) を含む溶性粘着分子のレベルが高くなり,冠動脈動脈疾患 (CAD) 患者における将来の心血管疾患による死亡を予測します. 溶解性VCAM-1は,致命的な心血管疾患の有意な独立した予測因子である.
科学分野:
- 心血管医学は,心臓血管医学である.
- 免疫学 免疫学とは
- バイオマーカー バイオマーカー
背景:
- VCAM-1,ICAM-1,E-セレクチンのような白血球粘着分子は,動脈硬化症の進行に寄与する.
- これらの分子は白血球の粘着と転移を媒介し,プラークの不安定性を引き起こす可能性があります.
研究 の 目的:
- 溶解性の粘着分子と,冠動脈疾患 (CAD) の患者における将来の心血管疾患との関連を調査する.
- 溶性粘着分子が確立された要因を超えてリスク予測を改善するかどうかを判断する.
主な方法:
- 血管学的に文書化されたCADを有する1246人の患者の前向きなコホート研究.
- 溶性VCAM-1 (sVCAM-1),sICAM-1およびsE-セレクチン.のベースライン測定
- 心血管疾患の追跡調査は,平均2.7年にわたって行われました.
主要な成果:
- sVCAM-1,sICAM-1,およびsE-セレクチン濃度の上昇は,心血管疾患による死亡の増加と関連していました.
- sVCAM-1の最高四分位にある患者は,致命的なイベントのリスクが2.1倍高かった.
- sVCAM-1は,hs-CRPのような炎症マーカーを考慮した後でも,心血管疾患による死亡の独立した予測因子であり続けました.
結論:
- 溶解性粘着分子,特にsVCAM-1は,CAD患者の将来の心血管疾患による死亡率と有意に関連しています.
- sVCAM-1は,従来の危険因子と心血管疾患による死亡に対するhs-CRPの予測価値を高めます.
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