フォスフォトリエステルの水解:重原子同位体効果による並列反応における移行状態の決定

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Updated: Jul 15, 2026

Time-resolved ElectroSpray Ionization Hydrogen-deuterium Exchange Mass Spectrometry for Studying Protein Structure and Dynamics
09:18

Time-resolved ElectroSpray Ionization Hydrogen-deuterium Exchange Mass Spectrometry for Studying Protein Structure and Dynamics

Published on: April 17, 2017

M A Anderson1, H Shim, F M Raushel

  • 1Institute for Enzyme Research and the Department of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin 53705, USA.

Journal of the American Chemical Society
|September 20, 2001
PubMed
まとめ

この研究では,O,O-ジエチルフォスフォリコルリンヨウ酸化物 (DEPC) とO,O-ジエチル-m-ニトロベンジル酸化物 (DEmNBP) のアルカリ性水解中に酸素-18同位体効果を測定しました. 大規模な一次および二次効果は,著しい圧縮による高度な関連性のある移行状態を示しています.

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