妊娠中の葉酸サプリメントと流産のリスク
1National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA 30341-3724, USA.
Lancet (London, England)
|September 21, 2001
まとめ
妊娠前期および妊娠初期に400mcgの葉酸を服用すると,流産のリスクに影響はありません. この研究では,葉酸のサプリメントが最初の妊娠における流産の発生に影響を与えるという証拠は見つかりませんでした.
科学分野:
- 産婦人科と産婦人科を担当しています.
- 生殖器保健は,生殖器の健康についてです.
- 栄養科学とは,栄養科学である.
背景:
- 妊娠前および妊娠中の葉酸補給 (400mcg) は,神経管欠陥 (NTD) のリスクを減らすことが知られている.
- 流産などの他の妊娠結果に対する葉酸の影響は,理解が薄いままです.
研究 の 目的:
- 葉酸サプリメントと流産のリスクとの関連を調査する.
- 妊娠前期および妊娠初期に摂取した400μgの葉酸が流産の発生に影響を与えるかどうかを判断する.
主な方法:
- 中国では,葉酸キャンペーンに登録した初めて妊娠した女性を対象にコホート研究が行われました.
- 妊娠前期および妊娠初期に400mcgの葉酸サプリメントを服用していたか,服用していなかったかの妊婦の妊娠結果を分析した.
主要な成果:
- 妊娠中絶の総割合は,研究集団で9.1%であった.
- 葉酸を服用している女性 (9.0%) と服用していない女性 (9.3%) は,同様の流産率 (リスク比0.97) を示した.
- 診断時の妊娠年齢と流産は,サプリメントを摂取したグループとサプリメントを摂取しなかったグループの間で比較可能でした.
結論:
- 妊娠前期および妊娠初期に1日400mcgの葉酸を摂取すると,この集団における流産リスクへの影響は示されなかった.
- この結果は,この用量での葉酸サプリメントは,流産の可能性を増加させたり減少させたりしないことを示唆しています.
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