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眼の毒性および,風湿性疾患のクロロクインまたはヒドロキシクロロクインの産前被曝
Lancet (London, England)
|September 21, 2001
まとめ
クロロクインとヒドロキシクロロクインは,リウマティック疾患に使用され,網膜症を引き起こす可能性があります. 妊娠中に被曝した21人の子供の眼科検査では,目の異常は認められず,リスクが低いことが示唆されています.
科学分野:
- オフタルモロジック (眼科)
- レウマトロジーの病理学
- 薬理学 薬理学とは
背景:
- クロロクインやヒドロキシクロロクインのようなリウマチ病の治療法は,色素性網膜症のリスクを伴う.
- これらの薬に対する子宮内被曝に関する安全性データは限られている.
研究 の 目的:
- 妊娠中のクロロクインおよびヒドロキシクロロクインの曝露による眼の安全性を評価する.
- これらの薬を使用している母親から生まれた子供の潜在的な眼科異常を評価するために.
主な方法:
- 母親が妊娠中にクロロクインまたはヒドロキシクロロクインを使用した21人の子供に眼科検査が行われました.
- 妊婦の薬物用量と妊娠中の被曝期間が記録された.
主要な成果:
- 検査された21人の子供のうち,眼科の異常は検出されなかった.
- 妊婦の平均日用量は,ヒドロキシクロロキンの317 mg,クロロキンの332 mgであった.
- 妊娠中の被曝の平均期間は7.2ヶ月でした.
結論:
- 妊娠中のクロロキンおよびヒドロキシクロロキンの治療的使用は,子孫に検出可能な眼性毒性をもたらさなかった.
- これらの発見は,これらの薬が治療的に使用された場合,胎児の眼球発達に対して比較的安全である可能性があることを示唆しています.
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