ガンマデルタT細胞による皮膚悪性腫瘍の調節

M Girardi¹, D E Oppenheim, C R Steele

¹Department of Dermatology and Yale Skin Diseases Research Core Center, King's College, London SE1 9RT, UK.

Science (New York, N.Y.)

|September 22, 2001

まとめ

ガンマ・デルタ・T細胞は,皮膚がんを予防する. これらの免疫細胞は,欠席すると,発がん性への感受性を高め,上皮の悪性腫瘍を調節する役割を強調します.

科学分野:

免疫学免疫学とは
皮膚科皮膚科について
腫瘍学腫瘍学

背景:

エピテリアの悪性腫瘍は,健康に重大な負担を及ぼします.
甲状腺組織免疫におけるガンマデルタT細胞の役割は,完全に理解されていません.
ガマデルタT細胞は,上皮組織に宿っていることが知られている.

研究の目的:

ガンマデルタT細胞の皮膚がん発生における役割を調査する.
ガンマデルタT細胞が皮膚がんの発症を予防または遅らせることができるかどうかを判断する.
ガンマデルタT細胞が上皮の悪性腫瘍を調節するメカニズムを解明する.

主な方法:

ガンマデルタT細胞が欠けているマウスモデルを使用した.
皮膚がんを誘発するために,様々な発がん物質に暴露されたマウス.
皮膚細胞のRae-1とH60分子の発現を分析した.
ガンマデルタT細胞と皮膚がん細胞を用いた in vitro アッセイを実施した.
NKG2d受容体-リガンド相互作用の役割を調査した.

主要な成果:

ガンマデルタT細胞が欠けていたマウスは,皮膚がんに対する感受性の増加を示した.
発癌物質への曝露は,皮膚細胞にRae-1とH60の発現を増加させた.
NKG2dを発現する皮膚関連ガンマデルタT細胞は,皮膚がん細胞をin vitroで効果的に殺した.
この殺戮メカニズムはNKG2dの関与に依存していた.

結論:

ガマデルタT細胞は,皮膚がん発生を予防する上で重要な役割を果たします.
NKG2d-Rae-1/H60経路は,ガンマデルタT細胞媒介による腫瘍監視に不可欠である.
局所的なガンマデルタT細胞は,保存された分子機構を使用して,上皮の悪性腫瘍を抑制します.

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