関連する実験動画

Updated: Jul 14, 2026

Bimolecular Fluorescence Complementation
08:54

Bimolecular Fluorescence Complementation

Published on: April 15, 2011

TCRをSlap-130/Fybybによるインテグリン活性化へのカップリング

E J Peterson1, M L Woods, S A Dmowski

  • 1The Abramson Family Cancer Research Institute, Department of Medicine, School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.

Science (New York, N.Y.)
|September 22, 2001
PubMed
まとめ

SLAP-130/FybはT細胞の活性化に不可欠であり,増殖と粘着に影響を与えます. 欠乏すると,T細胞受容体シグナル伝達が損なわれ,インテグリン機能と全体的なT細胞応答性に影響を及ぼします.

さらに関連する動画

A TIRF Microscopy Technique for Real-time, Simultaneous Imaging of the TCR and its Associated Signaling Proteins16:10

A TIRF Microscopy Technique for Real-time, Simultaneous Imaging of the TCR and its Associated Signaling Proteins

Published on: March 22, 2012

Measuring TCR-pMHC Binding In Situ using a FRET-based Microscopy Assay19:05

Measuring TCR-pMHC Binding In Situ using a FRET-based Microscopy Assay

Published on: October 30, 2015

関連する概念動画

Transducer Mechanism: Enzyme-Linked Receptors01:27

Transducer Mechanism: Enzyme-Linked Receptors

Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include: