酵母細胞サイクルにおける転写調節体のシリアル調節
I Simon1, J Barnett, N Hannett
1Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA.
Cell
|September 27, 2001
まとめ
酵母細胞周期の転写活性化剤は,周期的なネットワークを形成し,ある段階の活性化剤が次の段階の活性化剤を調節する. これは,細胞サイクル進行のための遺伝子発現と細胞イベントを制御する調整されたシステムを明らかにします.
科学分野:
- 分子生物学は分子生物学である.
- 遺伝学 遺伝学とは
- システム生物学 システム生物学
背景:
- 酵母細胞サイクルには,複雑な遺伝子発現プログラムが含まれています.
- 転写活性化剤は,これらのプログラムを調節する上で重要な役割を果たします.
- 調節ネットワークを理解することは,細胞サイクル制御を解読する鍵です.
研究 の 目的:
- 9つの既知の酵母細胞サイクル転写活性化剤の調節作用を解明する.
- 酵母細胞サイクルを制御する転写制御ネットワークをマッピングする.
- これらのアクティベーターがグローバルな遺伝子発現をどのように調整するかを理解する.
主な方法:
- ゲノム全体の位置分析が採用されました.
- 細胞サイクル転写活性化剤の間の調節相互作用を調査した.
主要な成果:
- 一つの細胞サイクル段階のアクティベーターが次の段階のアクティベーターを調節する連続調節パターンを特定しました.
- これらのアクティベーターが周期的な規制ネットワークを形成することを示した.
- グローバル遺伝子発現とステージ固有の機能の調整された調節を示した.
結論:
- 9つの転写活性化剤は,連結し,周期的な調節ネットワークを形成します.
- このネットワークは,酵母における細胞イベントの継続的なサイクルを駆動する.
- 細胞サイクルの転写制御ネットワークの基礎的な地図を提供します.
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