血管機能の前に,内皮細胞によって促進される肝臓器官生成

K Matsumoto¹, H Yoshitomi, J Rossant

¹Cell and Developmental Biology Program, Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA.

Science (New York, N.Y.)

|September 29, 2001

まとめ

初期の内皮細胞は,血管が機能する前に肝臓の発達を導く. 欠乏すると,適切な肝芽の成長が妨げられ,胚性臓器形成における重要な役割が強調される.

科学分野:

発達生物学発達生物学とは
血管生物学血管生物学とは
オルガノゲネシスオルガノゲネシス

背景:

初期オルガノゲネシスにおける内皮細胞と新生血管の役割は完全に理解されていません.
血管機能が臓器発育における内皮細胞の役割に先行するか,後に続くのかは不明である.

研究の目的:

肝臓の臓器形成における内皮細胞と新生血管の胚性役割を調査する.
血管機能が確立される前に,肝芽の形態変生のために内皮細胞が必要かどうかを判断する.

主な方法:

内皮細胞が欠けているFLK-1変異マウス胚の分析.
肝芽血管生成を研究するための胚組織エクスプラントシステムの開発.
エンドセリウム細胞の阻害は,肝臓の増殖への影響を評価するために,エクスペラント系での内皮細胞を抑制します.

主要な成果:

内皮細胞は肝臓内皮を囲み,肝臓芽の成長のためのメゼンキマ領域を定義します.
flk-1変異胚は正常な肝臓の特異性を示すが,肝臓の形態発生に失敗する.
エンドセリウム細胞の欠如または阻害は,肝臓の成長を選択的に阻害します.

結論:

血管新生性内皮細胞と新生血管は,オルガノゲネシスの初期段階に不可欠です.
内皮細胞は,血管機能とは無関係に肝臓の形態発生に重要な役割を果たします.

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