誤りやすいDNAポリメラーゼ:新しい構造と不貞の利点

E C Friedberg¹, P L Fischhaber, C Kisker

¹Laboratory of Molecular Pathology, Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. errol.friedberg@utsouthwestern.edu

Cell

|October 12, 2001

まとめ

新しく発見された,誤差に弱いDNAポリメラーゼは,その低信頼性を説明する新しい構造を持っています. これらの酵素は,複製中のDNA塩基損傷を回避するために不可欠です.

科学分野:

分子生物学は分子生物学である.
バイオケミストリーバイオケミストリー
遺伝学遺伝学とは

背景:

DNAポリメラーゼは,DNA複製と修復に不可欠である.
いくつかのDNAポリメラーゼは,トランスレション合成に不可欠な,誤りやすい活性を示します.
転移合成は,DNAの損傷を過ぎて複製を進めることを可能にします.

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