細胞メガロウイルスの血清陽性兄弟ドナーからの骨髄移植後の生存率
Lancet (London, England)
|October 13, 2001
まとめ
ドナー・サイトメガロウイルスの陽性性は,骨髄移植を受ける白血病患者の生存率を向上させ,特にHLA-A2陽性受容者の生存率を向上させます. これは,サイトメガロウイルスに特異的なT細胞からの増強された移植対白血病活性を示唆しています.
科学分野:
- 免疫学 免疫学とは
- 血液学 ヘマトロジ
- 腫瘍学 腫瘍学
背景:
- HLA同一の兄弟骨髄移植を受けた103人の白血病患者のアウトカムに対するドナー細胞メガロウイルス (CMV) 血清状態の影響を調査しました.
- CMVおよび白血病細胞に対するT細胞活動におけるHLA-A2制限の役割に焦点を当てた.
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