関連する実験動画

Updated: Jul 6, 2026

Pull-down of Calmodulin-binding Proteins
07:51

Pull-down of Calmodulin-binding Proteins

Published on: January 23, 2012

L型カルシウムチャネル-カルモジュリン複合体によって,MAPキナーゼ経路を通って核に信号を送る

R E Dolmetsch1, U Pajvani, K Fife

  • 1Division of Neuroscience, Children's Hospital and Department of Neurobiology, Harvard Medical School, Enders Pediatric Research Laboratories, Room 260, 300 Longwood Avenue, Boston, MA 02115, USA.

Science (New York, N.Y.)
|October 13, 2001
PubMed
まとめ

L型チャネル (LTC) 経由のカルシウムの流入は,神経細胞の生存と可塑性にとって不可欠な遺伝子発現を活性化させます. LTCの特定のIQモチーフはカルモジュリンと結合し,MAPK経路経由でカルシウムが核にシグナルを送信することを可能にします.

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