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Updated: Jul 8, 2026

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培養ニューロンと腫瘍細胞におけるポリアルファ2,8-シアル酸発現の小分子調節剤

L K Mahal1, N W Charter, K Angata

  • 1Department of Chemistry, Howard Hughes Medical Institute, University of California, Berkeley, CA 94720, USA.

Science (New York, N.Y.)
|October 13, 2001
PubMed
まとめ

研究者らは,N-ブタノイルマンノサミン (ManBut) がポリアルファ2,8-シアル酸 (PSA) の発現を逆転的に抑制できることを発見しました. この小さな分子は,代謝経路を通じてPSAの生物合成を妨害することで作用し,PSA媒介のイベントを研究するための新しい化学的ツールを提供します.

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