システミック・ルプス・エリテマトス症における心血管疾患のリスク要因
E Svenungsson1, K Jensen-Urstad, M Heimbürger
1Department of Rheumatology and Centre for Molecular Medicine, King Gustaf V Research Institute, Karolinska Hospital, Stockholm, Sweden. Elisabet.Svenungsson@medks.ki.se
Circulation
|October 17, 2001
まとめ
心血管疾患 (CVD) を患っている全身性白血球性狼 (SLE) 患者は,CVDのない患者と比較して,酸化LDLと脂質不全症を含む異なる危険因子を示します. これらの要因を特定することで,SLE患者のCVDリスクを管理するのに役立ちます.
科学分野:
- レウマトロジーの病理学
- 心臓病学 心臓病学
- 免疫学 免疫学とは
背景:
- 心血管疾患 (CVD) は,全身性白血病 (SLE) の患者において重大な懸念事項である.
- SLEにおけるCVDの特定の危険因子を理解することは,患者の管理に極めて重要です.
研究 の 目的:
- 既存のCVDとCVDのないSLE患者における従来のCVDおよび非従来のCVDリスク因子の有病率を決定する.
- これらのリスク要因を一般人口のコントロールグループと比較する.
主な方法:
- 3つのグループを対象とした比較研究:SLE患者とCVD (SLE症例),CVDのないSLE患者 (SLE対照),および集団対照.
- 動脈硬化症の代理として,超音波による一般的な頸動脈内側介質厚度 (IMT) の測定.
- 酸化LDL (OxLDL),OxLDLに対する自己抗体,トリグリセリド,HDLコレステロール,リポプロテイン (a),アルファ-1-抗トリプシン,狼抗凝固剤,ホモシステインレベルを含む血バイオマーカーの分析.
主要な成果:
- SLE症例は,SLE対照群および集団対照群と比較して,IMTの有意な増加を示しました.
- SLE症例では,OxLDL,OxLDLに対する自己抗体,トリグリセリド,リポプロテイン,アルファ-1-抗トリプシン,狼抗凝固剤,ホモシステインのレベルが高くなりました.
- また,SLE症例では,SLE対照群と比較して,骨粗鬆症の罹患率が高く,累積的なプレドニソロン投与量が高かった.
- SLE症例とSLE対照群の間の疾患の持続時間,喫煙,血圧,BMI,または糖尿病の有意な違いは観察されなかった.
結論:
- 独特のCVDリスク要因のセットは,CVDのSLE患者と,CVDのSLE患者と,一般の人々を区別します.
- これらの特定されたリスク要因は,SLE患者のCVDリスクによる階層化をするために潜在的に使用することができます.
- これらの発見を確認し,SLE患者におけるCVDリスク管理を最適化するために,将来的な研究が必要である.
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