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Cycloheximide Chase Analysis of Protein Degradation in Saccharomyces cerevisiae
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ヒストン脱セチラーゼ阻害剤は,ドロソフィラ菌におけるポリグルタミン依存性神経変異を抑制する

J S Steffan1, L Bodai, J Pallos

  • 1Department of Psychiatry and Human Behavior, Gillespie 2121, University of California, Irvine, California 92697, USA.

Nature
|October 19, 2001
PubMed
まとめ

拡張されたポリグルタミンタンパク質は,神経変性疾患を引き起こす. ヒストン脱酸化酵素 (HDAC) の抑制は,神経損傷を逆転させ,疾患モデルにおける致死率を低下させ,潜在的な治療を提供することができる.

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