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ウラシル-DNAグリコシラーゼは,基板の自己触媒作用によって作用する

A R Dinner1, G M Blackburn, M Karplus

  • 1Central Chemistry Laboratory, University of Oxford, South Parks Road, Oxford OX1 3QH, UK.

Nature
|October 19, 2001
PubMed
まとめ

Uracil DNA glycosylase (UDG) は,協調的な関連性ではなく,段階的な解離性メカニズムを通じてDNA修復を触媒化する. 酵素だけでなく,基質のリン酸塩は,活性化エネルギーを大幅に低下させ,予期せぬ自己触媒的貢献を明らかにします.

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