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An Optimized Hemagglutination Inhibition (HI) Assay to Quantify Influenza-specific Antibody Titers
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ヒトの血清アルブミンに対する afinity が低下したディフルニサルの類似体の合理的な設計

H Mao1, P J Hajduk, R Craig

  • 1Pharmaceutical Discovery Division, Abbott Laboratories, Abbott Park, Illinois 60044, USA.

Journal of the American Chemical Society
|October 25, 2001
PubMed
まとめ

研究者は,構造ベースの設計を導くために核磁共鳴 (NMR) を使用することによって,ヒト血清アルブミン (HSA) に薬剤化合物の結合を減少させた. この戦略により,抗炎症活性を維持しながら,HSAの afinityが低い化合物が得られました.

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