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Updated: Jul 14, 2026

09:29
Echocardiographic Assessment of the Right Heart in Mice
Published on: November 27, 2013
まとめ
この研究では,大動脈の完全な転移 (TGA) の患者のほとんどは,心室隔膜欠陥 (VSD) がなく,異常な右心機能を示し,右心室末端ダイアストリック容量 (RVEDV) の増加とエジェクション分数 (EF) の減少が特徴です. これらの発見は,TGA患者における右心房機能のモニタリングの重要性を強調しています.
科学分野:
- 心臓病学 心臓病学
- ペディアトリック・カルディオロジー
- 生まれながらの心臓病 生まれながらの心臓病
背景:
- 大動脈の完全転移 (TGA) は,手術による矯正を必要とする重大な先天性心不全です.
- TGA患者における血液動力学的状態と右心機能の術前理解は,管理に極めて重要です.
- TGAにおける右心機能の以前の評価は,詳細な体積分析を必要とし,変化していた.
研究 の 目的:
- 整形外科手術の前に完全なTGAを有する患者の右心と左心体積と機能を評価するために.
- TGA患者さんを,心室隔膜の状態と肺狭窄症に基づいて,血液動力学的グループに分類する.
- 異なるTGAサブグループにおける右心室機能不全の特定のパターンを特定する.
主な方法:
- 完全なTGAを患った24人の患者に心臓キャセテリゼーションを実施し,44件の研究結果が得られました.
- 患者は3つのグループに分類され,TGAは心室隔膜が無傷で,TGAはVSDで,TGAはVSDと肺狭窄でした.
- 右心室末端ダイアストリック容量 (RVEDV),エジェクション分数 (EF),シストリック出力 (SO) を測定し,正常値と比較した.
主要な成果:
- TGAと未損傷の心室隔膜を持つ患者は,RVEDVが有意に増加した (170%の正常値) と,RVEFが減少した (74%の正常値) を示した.
- TGAとVSDの患者は,高 RVEDV (163%の正常値) を示し,ほぼ正常な RV EF (91%の正常値) を示した.
- 右心房の体積の増加は,ほとんどの患者で観察されました; RVEDVは,多くの場合,有意な肺流量なしで,左心房の終末ダイアストリック容量を上回りました.
結論:
- 大多数のTGA患者,特にVSDのない患者は,手術前の右心機能障害を呈しています.
- 増加したRVEDVと減少したRV EFは,この集団における右心室機能不全の重要な指標です.
- 右心室機能の縦断的な評価は,TGAにおける治療戦略の評価に不可欠です.
関連する概念動画
Blood Flow
Blood is pumped by the heart into the aorta, the largest artery in the body, and then into increasingly smaller arteries, arterioles, and capillaries. The velocity of blood flow decreases with increased cross-sectional blood vessel area. As blood returns to the heart through venules and veins, its velocity increases. The movement of blood is encouraged by smooth muscle in the vessel walls, the movement of skeletal muscle surrounding the vessels, and one-way valves that prevent backflow.
Overview of the Heart
The heart, a muscular organ located in the chest, functions as the body's pump, circulating blood through the vascular system. It has four chambers: two atria on top and two ventricles below. The right atrium receives deoxygenated blood from the body and passes it to the right ventricle, which pumps it to the lungs for oxygenation. The left atrium receives oxygenated blood from the lungs and transfers it to the left ventricle, which pumps it to the rest of the body.
The heart's structure...
The heart's structure...
Location and Orientation of the Heart
The human heart, despite its modest size and weight, is an organ of remarkable strength and endurance. Roughly the size of a fist, the heart weighs between 250 and 350 grams and is nestled within the mediastinum, the medial cavity of the thorax. It extends obliquely for about 12 to 14 cm, resting on the superior surface of the diaphragm. The heart is positioned anterior to the vertebral column and posterior to the sternum, with two-thirds of its mass lying to the left of the midsternal line.
Chambers of the Heart
The human heart is a complex organ made up of four chambers: the right and left atria and the right and left ventricles. These internal chambers are separated by partitions known as the interatrial and interventricular septa. The exterior of the heart features a groove known as the coronary sulcus that demarcates the atria from the ventricles, while the anterior and posterior interventricular sulci distinguish between the two ventricles.
Deoxygenated blood from the body is received in the right...
Deoxygenated blood from the body is received in the right...
Coronary Circulation
The heart, an organ critical to survival, gets nourishment not from the blood it pumps but from a separate circulation system known as coronary circulation. This is the shortest circulation in the body and is responsible for supplying the heart with the nutrients it needs to function effectively.
Coronary circulation begins at the base of the aorta, where two main arteries arise—the left and right coronary arteries. These arteries encircle the heart in the coronary sulcus and supply the...
Coronary circulation begins at the base of the aorta, where two main arteries arise—the left and right coronary arteries. These arteries encircle the heart in the coronary sulcus and supply the...
The Aorta
The aorta is the largest artery in the human body. It originates from the left ventricle of the heart and extends down to the abdomen, where it splits into two smaller arteries. Structurally, it can be divided into four main parts: the ascending aorta, the aortic arch, the thoracic aorta, and the abdominal aorta.
The average diameter of the aorta is approximately 2-3 cm, but the size can vary depending on the section of the aorta and the individual's age, sex, and body size. The aorta is...
The average diameter of the aorta is approximately 2-3 cm, but the size can vary depending on the section of the aorta and the individual's age, sex, and body size. The aorta is...

