ビタミンCは,閉塞性心不全における内皮細胞アポトシスを阻害する

L Rössig¹, J Hoffmann, B Hugel

¹Molecular Cardiology, Department of Internal Medicine IV, University of Frankfurt, Germany.

Circulation

|October 31, 2001

まとめ

ビタミンC療法は,閉塞性心不全患者の内皮細胞アポトーシスを有意に減少させました. この抗酸化効果は,これらの患者の内皮機能を改善する可能性があります.

科学分野:

心血管研究循環器科の研究
細胞生物学細胞生物学
栄養科学とは,栄養科学である.

背景:

内皮細胞 (ECs) は,炎症と酸化ストレスによりアポトーシスを受けます.
閉塞性心不全 (CHF) は,全身の炎症,酸化ストレス,内皮機能不全によって特徴付けられます.
CHFにおけるECアポトーシスに対するビタミンCの影響を調査することは極めて重要です.

研究の目的:

CHF患者における内皮細胞アポトーシスに対するビタミンCの効果を決定する.
抗アポプトティック剤としてのビタミンCの有効性をインビトロおよびインビボで評価する.

主な方法:

実験室内研究では,腫瘍ネクロシス因子アルファとアンジオテンシンIIによって誘発されたECアポトシスに対するビタミンCの効果を評価した.
In vivo評価は,CHF患者におけるダブルブラインド・プラセボ対照試験を対象としたものです.
アポプトシスは,DNA断片化,DAPI染色,MTT測定,および循環するアポプトシス微粒子を用いて測定されました.

主要な成果:

ビタミンCの投与量に依存したECアポトーシスをin vitroで抑制した.
ビタミンCはミトコンドリアのサイトクロームCの放出とカスパース9の活性を低下させた.
CHF患者の場合,ビタミンCはプラズマのアポプトシス微粒子を著しく減少させ,ECの血清プロアポプトシス活性を抑制しました.

結論:

ビタミンCの投与は,CHFの患者における内皮細胞アポトーシスをin vivo抑制する.
このビタミンCの抗アポプトティック作用は,CHFにおける内皮機能に対する有益な影響に寄与する可能性があります.

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