ビタミンDの摂取量と1型糖尿病のリスク:出生コホート研究
E Hyppönen1, E Läärä, A Reunanen
1Department of Paediatric Epidemiology and Biostatistics, Institute of Child Health, WC1N 1EH, London, UK. e.hypponen@ich.ucl.ac.uk
Lancet (London, England)
|November 14, 2001
まとめ
幼児期の適切なビタミンDサプリメントは,1型糖尿病を発症するリスクの低下と関連しています. 十分なビタミンDの摂取を保証することは,この自己免疫疾患の発生率の増加を減らすのに役立ちます.
科学分野:
- 小児内分泌学について
- 栄養免疫学について
- エピデミオロジー エピデミオロジー
背景:
- 動物の研究では,ビタミンDのサプリメント摂取が1型糖尿病のリスクを低下させることを示唆しています.
- 乳児のビタミンD状態は,1型糖尿病の発症に影響を与える可能性があります.
- 1型糖尿病の発生率に対する早期のビタミンDの影響を調査する.
研究 の 目的:
- 幼児期におけるビタミンDの補給または欠乏が1型糖尿病の発症に影響するかどうかを判断する.
- 幼児のビタミンD摂取量と1型糖尿病の診断との関連性を分析する.
主な方法:
- フィンランド (12055人の妊婦 (1966年の出生年) の出生コホート研究.
- ビタミンDサプリメントの頻度/用量,および第一年のラキスに関するデータ.
- 1997年12月まで記録された1型糖尿病の診断.
主要な成果:
- ビタミンDのサプリメントは1型糖尿病の頻度の低下と関連していました.
- 定期的なビタミンD摂取量 (毎日2000 IU) は,リスクの低下を示した (RR 0.22).
- 幼児期におけるラキッツの疑いにより,1型糖尿病のリスクが増加した (RR 3.0).
結論:
- ダイエットビタミンDのサプリメント摂取は,1型糖尿病のリスク低下と関連しています.
- 適切な乳児のビタミンDサプリメントは,増加する1型糖尿病の発生率を逆転するのに役立ちます.
- 幼児のビタミンD摂取を促進する公衆衛生の取り組みは正当である.
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