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Updated: May 12, 2026

Detection and Analysis of DNA Damage in Mouse Skeletal Muscle In Situ Using the TUNEL Method
09:54

Detection and Analysis of DNA Damage in Mouse Skeletal Muscle In Situ Using the TUNEL Method

Published on: December 16, 2014

腫瘍死滅因子アルファ誘発性心不全におけるミトコンドリアの異常は,DNA修復活動の障害と関連しています

Y Y Li1, D Chen, S C Watkins

  • 1Cardiovascular Institute, Center for Biological Imaging, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

Circulation
|November 14, 2001
PubMed
まとめ

ミトコンドリアDNA修復活動の低下は,TNF-alpha.を過剰に発現するマウスの心不全に寄与する. これは,TNF-αがミトコンドリア機能障害とDNA変異を通して心臓損傷を媒介する可能性があることを示唆しています.

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Transmitochondrial Cybrid Generation Using Cancer Cell Lines

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