2型糖尿病のリスクマーカーとして,長いまたは非常に不規則な月経周期
C G Solomon1, F B Hu, A Dunaif
1Division of Women's Health, Brigham and Women's Hospital, 75 Francis St, Boston, MA 02115, USA. cgsolomon@bics.bwh.harvard.edu
JAMA
|December 26, 2001
まとめ
月経周期が長くまたは不規則な女性は,2型糖尿病を発症するリスクが2倍に増加します. この2型糖尿病 (DM) のリスクの増加は,肥満でない人でも存在します.
科学分野:
- エンドクリノロジー エンドクリノロジー
- 生殖器保健は,生殖器の健康についてです.
- メタボリック障害 メタボリック障害
背景:
- オリゴメノレアは,インスリン抵抗性やグルコース不耐症に関連しています.
- オリゴメノレアに関連した2型糖尿病 (DM) の潜在的なリスクは十分に確立されていません.
研究 の 目的:
- 長期または不規則な月経周期と2型DMの将来のリスクとの関連を将来的に評価する.
- 若い成人期の月経周期パターンが2型DMの発症を予測するかどうかを判断する.
主な方法:
- 将来の観察的看護師の健康研究IIコホートからのデータを活用した.
- DMの経験のない10万人以上の女性の18~22歳の月経周期パターンを分析した.
- 1997年までのフォローアップ期間中,2型DMの症例を追跡した.
主要な成果:
- 40日以上の月経周期または非常に不規則な周期を持つ女性は,2型DMのリスクが2.08倍増加しました.
- この高いリスクは,肥満でない女性を含む様々なボディマス指数カテゴリーで観察されました.
- 不規則な周期と2型DMリスクとの関連性は,肥満の女性ではより顕著でした.
結論:
- 長いまたは非常に不規則な月経周期は,将来の2型DMの発症の有意な予測要因です.
- 2型糖尿病のリスクの増加は,肥満だけによるものではない.
- 若い成人期の月経周期の規則性は,代謝の健康と将来の糖尿病リスクの指標として役立つ可能性があります.
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