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Updated: Jul 16, 2026

A New Approach for the Comparative Analysis of Multiprotein Complexes Based on 15N Metabolic Labeling and Quantitative Mass Spectrometry
08:04

A New Approach for the Comparative Analysis of Multiprotein Complexes Based on 15N Metabolic Labeling and Quantitative Mass Spectrometry

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ナキジキノノンの総合成と生物学的評価

P Stahl1, L Kissau, R Mazitschek

  • 1Department of Chemical Biology, Max-Planck-Institut für molekulare Physiologie, Otto-Hahn-Strasse 11, 44227 Dortmund, Germany.

Journal of the American Chemical Society
|November 22, 2001
PubMed
まとめ

研究者らは,Her-2/Neu腫瘍遺伝子の天然阻害体であるナキジキノンの最初のエナンチオセレクティブ合成を開発しました. 合成されたアナログは,腫瘍血管新生に不可欠なKDR受容体チロシンキナーゼを選択的に抑制する.

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