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関連する概念動画

Protein Complex Assembly02:41

Protein Complex Assembly

Proteins can form homomeric complexes with another unit of the same protein or heteromeric complexes with different types.  Most protein complexes self-assemble spontaneously via ordered pathways, while some proteins need assembly factors that guide their proper assembly. Despite the crowded intracellular environment, proteins usually interact with their correct partners and form functional complexes.
Many viruses self-assemble into a fully functional unit using the infected host cell to...
Protein Complexes with Interchangeable Parts01:57

Protein Complexes with Interchangeable Parts

Groups of proteins may form a complex where each protein in this complex has a different role in the overall execution of the complex’s function. Often some of the proteins in the complex can be replaced by a closely related variant to give a complex that contains many of the same components yet is functionally distinct.
The SCF ubiquitin ligase is a protein complex of five individual proteins. This complex attaches ubiquitin to other target proteins to mark them for degradation. In order to...
Synthetic Biology02:55

Synthetic Biology

Synthetic biology is an interdisciplinary science that involves using principles from disciplines such as engineering, molecular biology, cell biology, and systems biology. It involves remodeling existing organisms from nature or constructing completely new synthetic organisms for applications such as protein or enzyme production, bioremediation, value-added macromolecule production, and the addition of desirable traits to crops, to name a few.
Golden rice
Golden rice is a genetically modified...
ATP and Macromolecule Synthesis01:28

ATP and Macromolecule Synthesis

Biological macromolecules are organic compounds, predominantly composed of carbon atoms. The carbon atoms are covalently bonded with hydrogen, oxygen, nitrogen, and other minor elements. There are four major biological macromolecule classes: carbohydrates, lipids, proteins, and nucleic acids.
Most macromolecules are composed of single subunits, or building blocks, called monomers. The monomers combine with each other using covalent bonds to form larger molecules known as polymers.
Conversion of...
The Central Dogma01:20

The Central Dogma

The central dogma explains the flow of genetic information from DNA nucleotides to the amino acid sequence of proteins.
RNA is the Missing Link Between DNA and Proteins
In the early 1900s, scientists discovered that DNA stores all the information needed for cellular functions and that proteins perform most of these functions. However, the mechanisms of converting genetic information into functional proteins remained unknown for many years. Initially, it was believed that a single gene is...
Biosynthesis in Bacteria01:24

Biosynthesis in Bacteria

Biosynthesis in bacteria is a fundamental anabolic process that generates essential macromolecules, including proteins, nucleic acids, lipids, and polysaccharides. These macromolecules are critical for cellular growth, replication, and function. The process is tightly regulated and energetically linked to catabolic pathways to ensure optimal resource utilization.Biosynthetic pathways begin with precursor metabolites such as pyruvate, acetyl-CoA, and glucose-6-phosphate derived from glycolysis,...

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関連する実験動画

Updated: Jul 11, 2026

Designing a Bio-responsive Robot from DNA Origami
13:32

Designing a Bio-responsive Robot from DNA Origami

Published on: July 8, 2013

プログラム可能で自律的な計算機は,バイオ分子で作られています.

Y Benenson1, T Paz-Elizur, R Adar

  • 1Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot 76100, Israel.

Nature
|November 24, 2001
PubMed
まとめ

研究者らは,DNAと酵素を用いて,自律的な分子有限オートマットを開発した. このプログラム可能なDNAコンピュータは,高精度でナノスケールの計算問題を効率的に解決します.

科学分野:

  • バイオテクノロジー バイオテクノロジー
  • 分子コンピューティング
  • バイオインフォマティックス

背景:

  • オートマト理論は現代の計算を支えるものであり,チューリングマシンは初期のコンピュータ開発にインスピレーションを与えました.
  • データテープとDNAの類似性は,DNAコンピューティングの研究を推進しています.
  • 分子スケールの自律コンピューティングは依然として大きな課題です.

研究 の 目的:

  • 分子スケールで自律的に動作するプログラム可能な有限オートマトを記述する.
  • 計算上の問題を解くことができるDNAベースのコンピューティングデバイスを実証する.
  • 新しい自律的なシステムで分子コンピューティングの分野を前進させる.

主な方法:

  • DNAとDNA操作酵素 (制限ヌクレアゼとリガゼ) を用いて有限自動体を設計した.
  • 二重鎖DNA分子を用いてソフトウェアとインプットをエンコードした.
  • 自律的な処理のために,制限,ハイブリッド化,および結合サイクルのカスケードを使用しました.

主要な成果:

  • プログラム可能なDNAベースの有限オートマットを使用して,自律的な計算を達成しました.
  • 室温で小容量 (120ミクロリットル) の10^12自動機の並列動作を実証した.

さらに関連する動画

Automated Robotic Liquid Handling Assembly of Modular DNA Devices
11:22

Automated Robotic Liquid Handling Assembly of Modular DNA Devices

Published on: December 1, 2017

DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation
09:26

DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation

Published on: December 29, 2021

関連する実験動画

Last Updated: Jul 11, 2026

Designing a Bio-responsive Robot from DNA Origami
13:32

Designing a Bio-responsive Robot from DNA Origami

Published on: July 8, 2013

Automated Robotic Liquid Handling Assembly of Modular DNA Devices
11:22

Automated Robotic Liquid Handling Assembly of Modular DNA Devices

Published on: December 1, 2017

DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation
09:26

DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation

Published on: December 29, 2021

  • >99.8%のフィデリティと超低電力消費 (<10^-10W) とともに,毎秒10^9のトランジションの高いトランジション率を報告しました.

    • 結論:

    • 開発されたDNAベースの有限オートマトンは,自律的な分子コンピューティングに向けた重要な一歩を表しています.
    • このシステムは,ナノスケールコンピューティングのためのスケーラブルで効率的で低電力プラットフォームを提供します.
    • プログラム可能な性質と高性能は,複雑な分子レベルの問題解決の道を開く.