急性片頭痛の治療における経口トリプトン (セロトニン5HT1B/1Dアゴニスト):53件の臨床試験のメタ解析
M D Ferrari1, K I Roon, R B Lipton
1Department of Neurology, Leiden University Medical Centre, 2300 RC Leiden, Albinusdreef 2, 2333 ZA, Leiden, Netherlands. M.D.Ferrari@LUMC.NL
Lancet (London, England)
|December 1, 2001
まとめ
経口用トリプトンは,急性片頭痛の治療に有効です. 高用量リザトリプトン,エレトリプトン,アルモトリプトンは,一貫した片頭痛緩和の最良の機会を提供し,よく耐えます.
科学分野:
- 神経学 神経学とは
- 薬理学 薬理学とは
- クリニック・トライアル 臨床試験
背景:
- トリプトンはセロトニン5HT (セロトニン5HT,セロトニン5HT,セロトニン5HT,セロトニン5HT,セロトニン5HT,セロトニン5HT,セロトニン5HT,セロトニン5HT,セロトニン5HT,セロトニン5HT,セロトニン5HT,セロトニン5HT,セロトニン5HT,セロトニン5HT,セロトニン5HT,セロトニン5HT,セロトニン5HT,セロトニン5HT,セロトニン5HT,セロトニン5HT,セロトニン5HT,セロトニン5HT,セロトニン5HT,セロトニン5HT,セロトニン5HT,セロトニン5HT,セロトニン5HT,セロトニン5HT,セロトニン5HT,セロトニン5HT,セロトニン5HT,セロトニン5HT).
- 7種類のトリプタン製剤の入手が迫っているため,臨床選択のための根拠に基づいたガイドラインが必要です.
- 標準化された試験設計は,実践的な臨床指導のためのメタ分析を容易にする.
研究 の 目的:
- 経口トリプトンの臨床試験のメタ分析を行い,証拠に基づいた選択ガイドラインを確立する.
- 患者データを集約したデータに基づいて,様々な経口トリプトンの有効性と耐性を比較する.
主な方法:
- すべての関連する試験について,製薬会社や独立した研究者からデータを取得します.
- 片頭痛患者における口服トリプトンのダブルブラインド,ランダム化,制御試験のメタ解析.
- 直接比較試験を含む,有効性および耐受性パラメータの要約推定値の計算.
主要な成果:
- 患者24,089人を含む53件の臨床試験 (12件未発表) が含まれた.
- スマトリプタン (100 mg) は,頭痛反応の59%と2時間後に無痛率の29%を示した.
- リザトリプタン (10 mg) とエレトリプタン (80 mg) は,スマトリプタンと比較して優れた有効性と一貫性を示し,アルモトリプタン (12.5 mg) は,比較可能な2時間の有効性を示した.
- トリプトン薬の副作用率は一般的に低いが,エレトリプトン (80 mg) は耐受性が低い.
結論:
- すべての経口トリプトンは,有効であり,市場に出されている用量ではよく耐えます.
- リザトリプタン (10 mg),エレトリプタン (80 mg),アルモトリプタン (12.5 mg) は,一貫した片頭痛治療の成功率が最も高い.
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