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Updated: Jul 8, 2026

Measuring Biomolecular DSC Profiles with Thermolabile Ligands to Rapidly Characterize Folding and Binding Interactions
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薬物-DNA認識における協力性:分子ダイナミクス研究

S A Harris1, E Gavathiotis, M S Searle

  • 1School of Pharmaceutical Sciences, University Park, Nottingham NG7 2RD, UK.

Journal of the American Chemical Society
|December 14, 2001
PubMed
まとめ

分子動力学シミュレーションは,構造的およびエネルギー的要因だけではDNAへの結合協同性を説明できないが,構成エントロピーを組み込むことは,観察された実験結果を正確に予測することを明らかにする.

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