Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

5.0K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
5.0K
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

3.9K
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
3.9K
Diabetes Mellitus: Introduction01:26

Diabetes Mellitus: Introduction

56
Diabetes mellitus consists of chronic metabolic disorders characterized by persistent hyperglycemia. This elevated blood glucose results from defects in insulin secretion, impaired insulin action, or both. Insulin, produced by pancreatic β-cells, is essential for maintaining glucose homeostasis by facilitating cellular glucose uptake for energy or storage. Disruptions in insulin production or function lead to glucose accumulation in the bloodstream, causing the clinical features and...
56
Type I Diabetes II: Pathophysiology01:26

Type I Diabetes II: Pathophysiology

121
Type 1 diabetes mellitus arises from an immune-mediated destruction of pancreatic β-cells, resulting in an absolute deficiency of insulin. This process develops in genetically susceptible individuals when autoimmunity, environmental exposures, and immunologic dysregulation converge to trigger a targeted attack on the insulin-producing cells of the pancreas. The β-cells are located within the islets of Langerhans and are essential for regulating blood glucose by facilitating cellular...
121
Type II Diabetes I: Introduction01:26

Type II Diabetes I: Introduction

57
Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by insulin resistance, in which target tissues such as the liver, muscle, and adipose tissue respond poorly to insulin. It is also associated with inadequate compensatory insulin secretion, where pancreatic β-cells fail to produce sufficient insulin. Together, these abnormalities lead to persistent hyperglycemia.EtiologyT2DM develops through a complex interaction of genetic predisposition and environmental or...
57
Type II Diabetes II: Pathophysiology01:24

Type II Diabetes II: Pathophysiology

36
PathophysiologyType 2 diabetes mellitus (T2DM ) is a chronic metabolic disorder characterized by insulin resistance and progressive pancreatic β-cell dysfunction, leading to impaired glucose homeostasis. It results from interactions among genetic predisposition, environmental factors, and metabolic stressors, such as overnutrition and a sedentary lifestyle.Insulin Resistance and Glucose DysregulationEarly T2DM involves insulin resistance in skeletal muscle, adipose tissue, and the liver.
36

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Resting beta-cells - A functional reserve?

Diabetes & metabolism·2016
Same author

Cell-cell adhesion in the immune system.

Immunology today·2014
Same author

GSK-3β function in bone regulates skeletal development, whole-body metabolism, and male life span.

Endocrinology·2013
Same author

In vitro scan for enhancers at the TCF7L2 locus.

Diabetologia·2012
Same author

Association of the KCNJ11 variant E23K with type 2 diabetes in Indo-Trinidadians.

The West Indian medical journal·2012
Same author

Intrapancreatic delivery of human umbilical cord blood aldehyde dehydrogenase-producing cells promotes islet regeneration.

Diabetologia·2012
Same journal

Daily briefing: 'Cyborg' cockroaches breathe underwater with printed suit.

Nature·2026
Same journal

China boosts prestigious grants for young scientists - will it ease competition?

Nature·2026
Same journal

Incoming US science academy chief vows to 'double down' on research.

Nature·2026
Same journal

Author Correction: Synthesis of enantioenriched atropisomers by biocatalytic deracemization.

Nature·2026
Same journal

Electrodeposited self-assembled molecules for perovskite photovoltaics.

Nature·2026
Same journal

Neutrino's nursery found: the 'Shadow Blaster'.

Nature·2026
関連記事をすべて見る

関連する実験動画

Updated: May 5, 2026

A High-content In Vitro Pancreatic Islet β-cell Replication Discovery Platform
09:35

A High-content In Vitro Pancreatic Islet β-cell Replication Discovery Platform

Published on: July 16, 2016

10.4K

糖尿病とベータ細胞機能の遺伝的にプログラムされた欠陥

G I Bell1, K S Polonsky

  • 1Howard Hughes Medical Institute, Department of Biochemistry, Medicine and Human Genetics, The University of Chicago, Chicago, Illinois 60637, USA. g-bell@uchicago.edu)

Nature
|December 14, 2001
PubMed
まとめ
この要約は機械生成です。

糖尿病の遺伝的根拠を理解することは鍵です. インスリン分泌とベータ細胞質量を制御する遺伝子を特定することで,糖尿病に対する新たな洞察と潜在的な治療法が得られます.

さらに関連する動画

Generation of Scaffold-free, Three-dimensional Insulin Expressing Pancreatoids from Mouse Pancreatic Progenitors In Vitro
09:33

Generation of Scaffold-free, Three-dimensional Insulin Expressing Pancreatoids from Mouse Pancreatic Progenitors In Vitro

Published on: June 2, 2018

8.8K
Intramuscular Transplantation of Human Pluripotent Stem Cell-derived Pancreatic Endocrine Cells in Mice
06:53

Intramuscular Transplantation of Human Pluripotent Stem Cell-derived Pancreatic Endocrine Cells in Mice

Published on: April 10, 2026

123

関連する実験動画

Last Updated: May 5, 2026

A High-content In Vitro Pancreatic Islet β-cell Replication Discovery Platform
09:35

A High-content In Vitro Pancreatic Islet β-cell Replication Discovery Platform

Published on: July 16, 2016

10.4K
Generation of Scaffold-free, Three-dimensional Insulin Expressing Pancreatoids from Mouse Pancreatic Progenitors In Vitro
09:33

Generation of Scaffold-free, Three-dimensional Insulin Expressing Pancreatoids from Mouse Pancreatic Progenitors In Vitro

Published on: June 2, 2018

8.8K
Intramuscular Transplantation of Human Pluripotent Stem Cell-derived Pancreatic Endocrine Cells in Mice
06:53

Intramuscular Transplantation of Human Pluripotent Stem Cell-derived Pancreatic Endocrine Cells in Mice

Published on: April 10, 2026

123

科学分野:

  • エンドクリノロジー エンドクリノロジー
  • 遺伝学 遺伝学とは
  • メタボリック疾患

背景:

  • インスリン分泌と臓β細胞質量調節は,糖尿病の発症に不可欠である.
  • MODY (Maturity-onset diabetes of the young) は,ベータ細胞機能に影響を与える単一遺伝子の疾患を伴うもので,早期発症糖尿病につながる.
  • 2型糖尿病は,成人に影響する一般的な形態であり,異常なベータ細胞機能と,より広範な組織関与とともに,より定義されていない遺伝的基盤も特徴です.

研究 の 目的:

  • モノジェニック・糖尿病とポリジェニック・糖尿病の両方の遺伝的基盤を探求する.
  • インスリン分泌とベータ細胞質量における特定の遺伝子の役割を明らかにする.
  • 糖尿病の新たな治療標的を特定する.

主な方法:

  • モノジェニック・糖尿病 (MODY) の個体の遺伝子分析.
  • 一般的な2型糖尿病における感受性遺伝子の調査.
  • 保存された経路を特定するための比較ゲノミクス.

主要な成果:

  • 様々な形態の糖尿病の因果性および感受性遺伝子が特定されています.
  • これらの遺伝子は,インスリン作用と分泌経路に関する重要な洞察を提供します.
  • 遺伝的リンクを理解することは,病気のメカニズムを理解するのに役立ちます.

結論:

  • 遺伝子識別は,糖尿病の病原性を理解する上で極めて重要です.
  • 遺伝子研究からの洞察は,新しい糖尿病治療法の開発に情報を提供することができます.
  • 特定の遺伝経路をターゲットにすることは,将来の治療法にとって有望である.