低肝リパース活性症は,冠動脈疾患の新たな危険因子です

K A Dugi¹, K Brandauer, N Schmidt

¹Department of Internal Medicine I, Internal Medicine III, University of Heidelberg, Heidelberg, Germany. klaus_dugi@med.uni-heidelberg.de

Circulation

|December 19, 2001

まとめ

低肝脂酶 (HL) 活性は冠動脈疾患 (CAD) と関連しています. この発見は,HLがCADのリスク評価に役立つ可能性を示唆し,新しい治療法のターゲットになる可能性があることを示唆しています.

科学分野:

脂質代謝についてです.
心血管疾患に関する研究
バイオケミストリーバイオケミストリー

背景:

肝脂酶 (HL) は,脂質代謝において重要な役割を果たします.
HLの活動と冠動脈疾患 (CAD) の関連性は依然として議論されている.

研究の目的:

肝臓リパース活性と冠動脈疾患の程度との関係を調査する.
CADリスクのバイオマーカーとしてのHL活動の可能性を調査する.

主な方法:

冠動脈血管撮影を受けた200人の男性におけるヘパリン後プラズマのHL活性測定.
検証された範囲スコアを使用してCADの範囲を評価.
多変量分析を行い,HLプロモーター (-514Tアレル) の遺伝的変異を調べました.

主要な成果:

HLの活動とCADの程度 (r=-0.19,P<0.01) の間に有意な逆相関が認められた.
CADの患者は,対照群と比較して,HLの活性が低かった (286+/-106 vs. 338+/-108 nmol.mL(-1).min(-1),P<0.01).
HLプロモーター-514 Tアレルは,HLの活性低下とCADの範囲の増大と関連していました.

結論:

低肝リパース活性が冠動脈疾患と独立して関連している.
HLの活動は,CADのリスクを推定するための貴重なツールとして役立つかもしれません.
HLは,CADの管理における将来の薬理学的介入の潜在的なターゲットである可能性があります.

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