閉経後の女性のビタミンA摂取量と股関節骨折
Diane Feskanich1, Vishwa Singh, Walter C Willett
1Channing Laboratory, 181 Longwood Ave, Boston, MA 02115. diane.feskanich@channing.harvard.edu
JAMA
|January 12, 2002
まとめ
高いビタミンA摂取量,特にレチノール摂取は,閉経後の女性において,股関節骨折のリスクの増加と関連しています. これは,食品やサプリメントにおけるビタミンAの推奨摂取量を再評価する必要があることを示唆しています.
科学分野:
- 栄養学的流行病学について
- 骨の健康に関する研究
- 公衆衛生 栄養 栄養について
背景:
- ビタミンAの摂取量が高く,動物における骨の改造に悪影響を及ぼすことが知られている.
- ヒトの骨折リスクに対する長期にわたる高ビタミンA摂取の潜在的貢献について懸念があります.
研究 の 目的:
- 食物とサプリメントの両方からの高ビタミンA摂取量と,閉経後の女性における股関節骨折のリスクとの関連性を調査する.
主な方法:
- 看護師の健康研究から72,337人の閉経後の女性を対象とした前向きなコホート研究で,18年間の追跡調査を行った.
- ビタミンAの摂取量 (総量,レチノール,ベータカロテン) とサプリメントの使用は,ベースラインで評価され,更新されました.
- 事件性股関節骨折は,ビタミンA摂取量のクインチルに関連して分析されました.
主要な成果:
- 総ビタミンA摂取量 (≥3000μg RE/day) の最高クインチルの女性では,股関節骨折のリスクが著しく高かった (RR, 1.48).
- このリスクの増加は主にベータカロテンではなく,レチノールの摂取量 (RR, ≥2000μg/日に対して<500μg/日で1.89) と関連していました.
- 食物からのレチノールの高摂取は,骨折リスクと有意に関連しており,特にサプリメントを摂取していない女性では特にそうでした.
結論:
- レチノールの高量を長期にわたって摂取すると,女性の骨粗鬆性股関節骨折のリスクが増加する可能性があります.
- 強化食品とビタミンサプリメントのレチノールの現在のレベルは,潜在的な骨格的リスクを軽減するために再評価を正当化します.
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